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In the intestine, Notch interacts with Wnt signaling to regulate progenitor plasticity during crypt regeneration [25, 26]

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At the same, unlike classical lattice protein-mediated endocytosis of Tf receptors, this drug is also known as ferritin due to its different previous endocytosis pathway that induces internalization and degradation of unoccupied Tf receptors (Horonchik and Wessling-Resnick, 2008)