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One aspect of the invention pertains to small molecule quinoline derived cations of Formula I, wherein: R 1 is C 1-4 alkyl

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Response: We appreciate and acknowledge these comments related to the implementation of the transfer of care modifiers proposal

An intact HPA axis appears to serve as an inhibitory feedback system, as both central CRF agonists and systemic glucocorticoid administration significantly inhibit ghrelin secretion, whereas adrenalectomy-induced elimination of corticoids potentiates fasting-induced ghrelin elevation, an effect that can be normalized by glucocorticoid replacement