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Antioxidant defense system Liver glutathione (GSH), a non-enzymatic antioxidant of the hepatic antioxidant defense system, and the activities of different antioxidant enzymes, namely catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx), were determined as previously described (Degrave et al

The two probes were highly sensitive to pH fluctuations (especially at the range of 5.504.00, with pKa values of 4.72 and 4.45) and could be reversibly turned off and on by alternating the pH values

We observed an expansion of the MPP1 population in both aged WT and Mda5 -/- animals, but to a lesser degree in the aged Mda5 -/- (Supplementary Fig

10.1016/j.mtbio.2023.100823 51 PridgenE