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In addition, research has demonstrated that specific inflammatory genes, including IL-1, IL-6, and TNF-, are prominently expressed in endothelial cells, fibroblasts, and macrophages in older populations with POP

Chen Y, Wang Y, Chen J, Chen X, Cao W, Chen S, et al

The Role of MDM2 Amplification and Overexpression in Tumorigenesis

These microenvironmental constraints can limit iron availability, activating adaptive pathways such as HIF-1, which promotes metabolic adaptation and tumor invasiveness ( Due to their rapid growth and proliferation, tumor cells have an increased demand for iron, disrupting iron metabolism