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Simultaneously, several meta-analyses and guideline panels highlight that many claimed indications are supported only by low- to moderate-quality evidence, with significant heterogeneity between trials and frequent failure of some strains or formulations to demonstrate superiority over placebo in rigorous, well-controlled studies (2, 3)

This narrative review integrates biochemical, preclinical, and clinical data to map age-dependent changes in the serine/glycine, glutamine/glutamate, arginine/citrulline, cysteine/trans-sulfuration, and alanine cycles, examines their impact on osteogenesis and mucosal healing, and evaluates nutritional or pharmacological strategies to restore NEAA sufficiency

PPAR/ prevents inflammation and fibrosis during diabetic cardiomyopathy

Our aim is to identify novel biomarkers of AD in tear fluid, to assess their diagnostic utility, and to provide new insights into the underlying disease mechanisms