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For instance, global transcriptomic analyses have revealed reduced expression of several antioxidant enzymes in ovulated oocytes recovered from aged mice and human donors 4, 30, 31

Biomedicine & Pharmacotherapy, 57, 145-155

As has been reported with grapefruit juice, time-dependent inhibition of CYP3A can result in irreversible loss of protein, requiring de novo synthesis to restore enzyme activity over a time course dictated by the half-life of CYP3A protein