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While all Cbl initially enters the bloodstream bound to TCN2, only about 2030% of the total blood cobalamin is transported by TCN2 and is thus in the biologically active form, with the remaining 7080% bound to Hc [89]

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This method can bypass potential barriers related to digestion, making it a particularly effective choice for individuals with gastrointestinal disorders or those who have had bariatric surgery

Cobalamin is an essential cofactor in red blood cell synthesis