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These excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells, resulting in complicated medical symptoms including fever, capillary leak syndrome, disseminated intravascular coagulation, acute respiratory distress syndrome, and multiorgan failure, ultimately leading to death in the most severe cases

However, phytovagex (a black cumin formulation indicated for vaginal fungal infection) and black cumin oil applied to pregnant rats as an intravaginal pessary in the first half of pregnancy did not cause any adverse effect on the duration of pregnancy and health parameters of the offspring [337,338]

Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds

The morphological changes of the main branches of the DPNs were observed to be very mild, with almost no significant changes on the H&E slides in our study