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coli Nissle 1917 EMA European Medicines Agency EMT Epithelial-mesenchymal transition EPS Extracellular polysaccharides ERK Extracellular signal-regulated kinase ESCC Esophageal squamous cell carcinoma FDA Food and Drug Administration FFAR2 Free fatty acid receptor 2 FGF15 Fibroblast growth factor 15 FMT Fecal microbiota transplantation FOXM1 Forkhead box M1 FOXO1 Forkhead box O1 FOXO3 Forkhead box O3 FXR Farnesoid X receptor GA Gallic acid GAPDH Glyceraldehyde-3-phosphate dehydrogenase GCDCA Glycochenodeoxycholic acid GEMM Genetically engineered mouse model GLCA Glycolithocholate GPCR/GPR G protein-coupled receptor GPX4 Glutathione peroxidase 4 H3K27 Histone H3 lysine 27 HCC Hepatocellular carcinoma HDAC Histone deacetylase HIF-1 Hypoxia-inducible factor 1 HLA Human leukocyte antigen HSC Hepatic stellate cell HSD High-salt diet I3A Indole-3-aldehyde I3C Indole-3-carbinol IAA Indole-3-acetic acid ICA Indole-3-carboxylic acid ICD Immunogenic cell death ICI Immune checkpoint inhibitor ICOS Inducible T-cell co-stimulator ID2 Inhibitor of DNA binding 2 IDA trans-3-Indoleacrylic acid IDO Indoleamine 2,3-dioxygenase IFN Interferon IFNAR1 Interferon alpha/beta receptor 1 IL Interleukin ILA Indole-3-lactic acid ILK Integrin-linked protein kinase IPA Indole-3-propionic acid irAEs Immune-related adverse events JAK3 Janus kinase 3 Kyn Kynurenine LAG3 Lymphocyte-activation gene 3 L-Arg L-arginine LCA Lithocholic acid LPS Lipopolysaccharides LTA Lipoteichoic acid mAbs Monoclonal antibodies MAdCAM-1 Mucosal addressin cell adhesion molecule-1 MAPK Mitogen-activated protein kinase MD2 Myeloid differentiation protein 2 MDSC Myeloid-derived suppressor cell MET4 Microbial Ecosystem Therapeutics 4 mitoROS Mitochondrial reactive oxygen species MMP Matrix metalloproteinase MSI-H Microsatellite instability-high MSI-L Microsatellite instability-low MSS Microsatellite-stable mTOR Mechanistic target of rapamycin MyD88 Myeloid differentiation primary response 88 NAFLD-HCC Non-alcoholic fatty liver disease-related hepatocellular carcinoma NFAT Nuclear factor of activated T cells NF-B Nuclear factor B NK Natural killer NKT Natural killer T NLRC5 NLR family CARD domain containing 5 NO Nitric oxide NOD2 Nucleotide-binding oligomerization domain-containing protein 2 NSCLC Non-small cell lung cancer OMV Outer membrane vesicle OS Overall survival PBMC Peripheral blood mononuclear cell PD-1 Programmed death-1 PDAC Pancreatic ductal adenocarcinoma PD-L1 Programmed death-ligand 1 PERK Protein kinase R-like endoplasmic reticulum kinase PFS Progression-free survival PGA Polygalacturonic acid PGE2 Prostaglandin E2 PI3K Phosphatidylinositol-3-kinase Pink1 PTEN-induced kinase 1 PMCA Plasma membrane Ca POSTN Periostin PPAR- Peroxisome proliferator-activated receptor gamma PRR Pattern recognition receptor QDPR Quinoid dihydropteridine reductase RA Retinoic acid RAGE Receptor for advanced glycation end-products RCC Renal cell carcinoma RORt Retinoic acid-related orphan receptor gamma t ROS Reactive oxygen species SASP Senescence-associated secretory phenotype SCC Squamous cell carcinoma SCFA Short-chain fatty acid sIgA Secretory IgA SLC7A11 Solute carrier family 7 member 11 STAT Signal transducer and activator of transcription STING Stimulator of interferon genes TAM Tumor-associated macrophage TBX21 T-box21 Tc1 Type 1 cytotoxic T cell TCA Taurocholic acid TCF-1 T-cell factor 1 Tcm Central memory T cells TCR T-cell receptor TDCA Taurodeoxycholic acid TFEB Transcription factor EB TGF- Transforming growth factor-beta TGR5 G protein-coupled bile acid receptor 5 TIFA TRAF-interacting protein with a forkhead-associated domain TIGAR TP53-induced glycolysis and apoptosis regulator TIL Tumor-infiltrating lymphocyte TLCA Taurolithocholic acid TLR Toll-like receptor TMA Trimethylamine TMAO Trimethylamine N-oxide TME Tumor microenvironment TNBC Triple-negative breast cancer TNF Tumor necrosis factor Tpex Progenitor-exhausted T cell TRAF Tumor necrosis factor receptor - associated factor Treg Regulatory T cell Trp Tryptophan T SCM T memory stem cell UA Urolithin A UB Urolithin B UBA6 Ubiquitin-like modifier activating enzyme 6 UDCA Ursodeoxycholic acid ULK1 Unc-51 like autophagy activating kinase 1 UTMD Ultrasound targeted microbubble destruction VEGFA Vascular endothelial growth factor A VEGFR2 Vascular endothelial growth factor receptor 2 VM Vasculogenic mimicry WNK1 With-no-lysine (K) 1 YBX1 Y-box binding protein 1

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