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The NASEM report also found: Moderate evidence that more frequent use of e-cigarettes is associated with an increased likelihood of cessation of conventional cigarettes Limited evidence that e-cigarettes may be effective aids to promote smoking cessation Conclusive evidence that e-cigarette use increases airborne concentrations of particulate matter and nicotine in indoor environments compared with background levels Conclusive evidence that most e-cigarette products, in addition to nicotine, contain and emit numerous potentially toxic substances Evidence on short-term exposure to e-cigarettes and health effects exists but is not conclusive Introduction On September 12, 2018, U.S

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Twin studies [3] and heritability estimation based on genome-wide association studies (GWASs) [4, 5] indicated that genetic factors contribute far less to incident lung cancer than environmental factors, including smoking