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Furthermore, emerging reports in both animals and humans indicate that NNMT plays a role in obesity and related chronic metabolic conditions (e.g., type-2 diabetes)

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5-Amino-1MQs confirmed high selectivity documented not to inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes makes it the most validated small-molecule NNMT research tool currently available, and ensures that experimental findings can be reliably attributed to NNMT inhibition rather than off-target effects