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1 Introduction Paclitaxel is a highly effective chemotherapeutic agent widely used in the treatment of various cancers, including breast, ovarian, lung, head, and neck cancers (Abu Samaan et al., 2019)

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first proposed the concept of oxidative stress, either caused by an increase in free radical production or a reduction in the scavenging capacity of the body, leading to disorders in the oxidation and antioxidant systems, resulting in oxidative damage by free radical accumulation (Sohal and Allen, 1990)

The percentage of time spent with the novel object was calculated by dividing the time the mouse spent exploring the novel object (O1) by the sum of the time spent exploring the novel object (O1) and the familiar object (O2) and then multiplying the result by 100 [110, 111]