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Direct support for the idea that genes held in this bivalent state are susceptible to methylation was provided by analyses of individual clones of stem cells containing ectopically overexpressed BMI1 (BMI1 is a central component of PRC1 involved in recognition of the H3K27me3 mark, established by EZH2, and has a role in subsequent maintenance of PcG-mediated long-term gene silencing)