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With the definition of ferroptosis, increasing research has demonstrated that amino acid metabolism is closely related to the regulation of ferroptosis ( Cystine/glutamate transporter (System Xc-) is an amino acid antiporter that mediates the exchange of extracellular cystine and intracellular glutamtate across the plasma membrane (Tu et al., 2021

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Assay of nicotinamide nucleotide transhydrogenases in mammalian, bacterial, and reconstituted systems