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Carbamylation is a translational modification in NETs of RA patients, and carbamylated NETs (cNETs) guide the rapid formation of osteoclasts (OCs) from monocytes and accelerate bone erosion in RA (146)

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Patients in combination therapy group received PEG-IFN-2b for 12 weeks followed by TDF add-on for 36 weeks, TDF monotherapy group received TDF for 48 weeks and control group received follow-up only (Figure 1A)

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