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Matrine Matrine, a natural alkaloid compound from Radix Sophorae Flavescentis, exhibits well-established anticancer activity by inhibiting proliferation, inducing apoptosis, suppressing metastasis, and weakening cancer stemness, making it a promising anticancer small molecule [221]

Although astrocyte dysfunction and iron dysregulation are increasingly recognized in AD pathology, their direct causal link to disease progressionand particularly to hypothesized central mechanisms such as ferroptosisrequires further validation in human contexts

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Glutathione Dosing Across Clinical Conditions and Evidence Glutathione dosing varies significantly by clinical application