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The most common material used for dental fillings is a composite resin filling, but that is not the only kind of filling dentists use

4.4 Systemic sclerosis As a consequence of dysfunctional differentiation of fibroblasts to myofibroblasts and excessive deposition of extracellular matrix, systemic sclerosis (SSC) is a rare fibrotic autoimmune disease that leads to skin fibrosis (83)

M F Gerhards, T M Karsten, L C de Nes, H Rijna (Department of Surgery, Onze Lieve Vrouwe Hospital, Amsterdam)

In the present study, we found that Protandim-mediated protection against salt-induced endothelial dysfunction (presumably via NRF2 activation) was prevented by inhibiting NOS by L-NAME in isolated MCAs (Supplement Figure 1), indicating that NO bioavailability is improved in Protandim-supplemented animals