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In experimental models of diabetic kidney injury, long-term treatment with selective COX-2 inhibitors and PGE 2 receptor antagonists improves functional and structural kidney injury in these conditions

By eliminating tumor stem cell populations with high ALDH activity and combining with PARP inhibitors that target the bulk tumor cells, it can more thoroughly eradicate the tumor, prevent recurrence, and overcome PARP inhibitor resistance mediated by cancer stem cells (63).A similar mechanism is observed in its combination with doxorubicin

Chang Gung Med J 35 , 211218 (2012)

In reality, oxidative stress may only be a secondary or downstream factor in many pathological processes