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Front Cell Infect Microbiol 5:95 Shaw SY, Blanchard JF, Bernstein CN (2010) Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease

this is termed a secondary IV, or IV piggyback

The results of longitudinal studies the results are variable: some have observed a decrease in the relapse phase, followed by an increase 31 Obradovic et al

[,] Owing to acute liver failure, chronic hepatitis, or cirrhosis, the clearance of ammonia by the liver is diminished, they may reach to the brain, the elevated levels of ammonia and an inflammatory response work in synergy to cause astrocytes to swell and fluid to accumulate in the brain (cerebral edema), thus, affect cerebral function [,] [Figure 7]