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However, although multiple TCMs and NPs have shown promising therapeutic effects at both the cellular and animal levels, research on their transformation and clinical application is seriously insufficient, which is represented in Table 1

That observation was reproduced in these experiments (Figure 2)

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Typical usage dose ranges anywhere from 0.2-4.8% depending on how much oil is in the formula, and this ingredient works across a wide pH (4-11) + temperature range