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It also strengthens antioxidant defenses, which may help improve skin appearance, reduce oxidative stress, and support immune health

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For instance, elevated 4-HNE in synovial fluid has been reported in multiple studies, but significant variations in detection methods and patient stratification such as disease stage and inflammation degree between studies mean the strength of evidence for 4-HNE as a driver of OA inflammation amplification still requires cautious interpretation

Disruption of the regional homeostasis of ERMCS affects their remodeling ability, leading to impaired intercellular communication and even the occurrence of ALS