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Shikonin targets TrxR and induces oxidative stress to promote apoptosis in gefitinib-resistant non-small cell lung cancer cells, with decreases in NADPH and the GSH/GSSG ratio [163]

Statistics and reproducibility The students t test was used to compare the differences between two independent groups, and one-way or two-way analysis of variance (ANOVA) was used for comparisons among three or more groups