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Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)

Most experts and clinical studies suggest that taking 2,000 mg (or 2 grams) per day is a safe and effective upper limit for most healthy adults

Acknowledgments The authors would like to thank Erik Brouwer from SOBI, Swedish Orphan Biovitrum for his valuable contribution

There may exist undiscovered bridges involving CPTIA that coordinate the three biological processes, which is crucial to the metabolic adaption in cancer