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In addition to DNAm, cigarette smoking is linked to the activation of enzymes that regulate other types of epigenetic modifications (i.e., post-translational modifications of histones via methylation, acetylation, phosphorylation, ubiquitination, and regulation of non-coding RNA sequences) to mediate the expression of multiple inflammatory genes, thereby participating in the onset development of autoinflammatory diseases (135)

Research shows that collagen supplementation can reduce the risk of atherosclerosis the buildup of plaque on the walls of arteries a component of heart disease