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While these results have yet to be replicated in human clinical trials, the studys authors suggested that as Fragment 176-191 does not stimulate the production of IGF-1, it may be safer than human recombinant GH for the long-term treatment of OA [10]

[123] The metabolism of NAD + remained an area of intense research into the 21st century, with interest heightened after the discovery of the NAD + -dependent protein deacetylases called sirtuins in 2000, by Shin-ichiro Imai and coworkers in the laboratory of Leonard P

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