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If you notice persistent dark yellow or tea-colored urine, its important to see your doctor and adapt your diet accordingly to support kidney health

In newborn screenings where biochemical markers are indicative of vitamin B 12 deficiency, the diagnosis of inborn errors of vitamin B 12 metabolism is performed via functional studies on cultured fibroblasts isolated from skin biopsies (Watkins and Rosenblatt, 2013) or via molecular genetic analysis of putative genes

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Other rare symptoms may include irritability, microcephaly, autism spectrum disorder, tremor, global developmental delay, coma, polyneuropathy, axial hypotonia, and daytime sleepiness [100, 102,103,104,105,106,107,108]