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Patients with renal fibrosis exhibit increased expression of the deubiquitinating enzyme USP11, which positively correlates with the severity of renal fibrosis

b - d , 3-month-old Mx1-Cre and Mx1-T3 mice were treated with -glucan or PBS and Lineage-negative cells were harvested 7 days later, differentiated into myeloid cells, treated with -glucan or PBS, further differentiated before LPS induction for 24 hr for cytokine production

Metabolites 11(1):51 Schumann A et al (2023) The impact of metabolic stressors on mitochondrial homeostasis in a renal epithelial cell model of methylmalonic aciduria

While cortisol at high levels for extended periods is detrimental to your health, the modest and short-term increase described above is a natural and healthy reaction to a shock