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found that astrocytic sigma-1 receptor can exert antidepressant-like effects through promoting CD38-driven mitochondrial transfer [55]

dose released is approximately 65 mcg/day Leuprolide: intramuscular injection (weight-based dosing)

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On the testosterone side, the side effect profile is whatever your existing TRT protocol already carries: this stack doesn't change your hormone dosing, so it doesn't add new hormone-related risk on top of what your clinician is already monitoring