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NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

The same 2mg dose from a 10mg/mL concentration requires 0.2mL (20 units), offering better accuracy and consistency across multiple draws

5-Amino-1MQ is a high-purity research compound supplied in capsule form for laboratory and analytical applications