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However, studies such as double-blind clinical trials with larger samples are needed to further demonstrate the efficacy of vitamin D analogs in combination with other traditional therapies in patients with alopecia areata

Whilst systemic corticosteroids and conventional immunomodulators have been the primary therapeutic agents, evolving strategies, including biologics and small molecules targeting tumour necrosis factor, different cytokines, or Janus kinase signalling pathways, signify a shift towards a precision management paradigm that considers individual clinical presentations

10.1016/j.envexpbot.2010.10.004 51 GardinerS