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Creatine is an organic compound produced in the body from three amino acids (methionine, glycine, and arginine) found in certain foods like red meat, poultry, and fish

Barbieri RL, Ehrmann DA

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Patients may look to supplements to manage ME/CFS for many reasons, for example, because of lack of medication options offered by clinicians, preference for complementary and integrative methods, or sensitivity to pharmaceuticals