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If the E4 peptide proves effective at reducing fibrosis in organs beyond the lungs and the skin, it could have potential as an antifibrotic therapy in those patients as well

The failing heartan engine out of fuel

Human monocyte-derived dendritic cells express TrkB, and BDNF modulates their maturation, implying that BDNF/TrkB can alter antigen-presenting cell function and subsequent T-cell priming ( Careful anatomical and temporal annotation of receptor signaling, together with explicit consideration of murinehuman differences in NGF/BDNF expression, Trk isoforms, ligand affinity and immune-cell repertoires, is required to relate cell-intrinsic effects to stromal and immune phenotypes and to gauge the translational limits of murine OS models

promote angiogenesis (the formation of new blood vessels)