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As such, the first three PCs explained 62% of the variance of the original data set, with PC1 describing 41%, PC2 describing 13%, and PC3 describing 8% of the total variance, with principal component analysis (PCA) clearly dividing cells into four different clusters matching their groups (Figure 2C)

The participants then returned a few days later to undergo cognitive testing, dualenergy xray absorptiometry (DEXA) scan and metabolic studies

Cereblon-based PROTACs are considered the most oral drug-like due to their cereblon ligase ligands

Common side effects Most reported side effects are mild and transient: Injection site reactions: Redness, mild swelling, or itching at injection sites