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However, the immunogenicity of recombinant protein therapeutics remains a major concern, and optimized tools are needed to measure ADA levels and appropriately interpret the results in drug safety assessments

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The majority of them include gastrointestinal problems and skin, respiratory, cardiovascular or neurological problems, especially when histamine intolerance occurs, and in severe cases, this can lead to histamine toxicity

Significant alterations at 12 h with an APAP lethal dose were observed for ALT levels and 12 miRNAs: 574-5p, 135a*, 466 g, 1196, 466f-3p, 877, 342-3p, 195, 375, 29c, 148a and 652