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of this final rule, we finalized revisions to 423.160(a)(5) to specify that prescriptions written for a beneficiary in a long-term care (LTC) facility will not be included in determining CMS EPCS Program compliance until January 1, 2028, and that compliance actions against prescribers who do not meet the compliance threshold based on prescriptions written for a beneficiary in a LTC facility will commence on or after January 1, 2028

The omnipresence of these enzymes in all types of organisms highlights an ancient origin as well as fundamental functions preserved during evolution

However, this result is expected considering the very high activity of glutaredoxins as deglutathionylating enzymes and a decreased GSSR concentration neither excludes mechanism (ii) or (iii) from Fig