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Discussion PTMs is a biological process in which small-molecule substrate, such as acetyl-CoA, crotonyl-CoA, butyryl-CoA, phosphate, etc, is covalently bound to a specific amino acid residue of proteins in a reversible manner

Morphologically, ferroptosis differs significantly from apoptosis, necrosis, and autophagy, with four main characteristics: (1) Iron dependency: the process of ferroptosis requires the involvement of iron, which is the primary reason for its naming

During the acute phase of ischemic stroke, anti-inflammatory M2 microglia show a brief increase followed by a rapid decline