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Although the results for probing depth and gingival recession were not statistically significant, the single injection group demonstrated a significant therapeutic effect in improving bone defect depth (P = 0.0083)an outcome that is challenging to achieve with current non-surgical clinical treatments (Supplementary Table 11)

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After planning the treatment, preparation is followed

Both melphalan and chlorambucil are larger molecules than most of the compounds studied in this work, and they possess aromatic rings in their chains, which increases their hydrophobicity