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GO enrichment analysis suggested that the autophagy-related upregulated DEGs were enriched in pathways closely related to the cell cycle, cell proliferation, antioxidant stress, and energy metabolism functions, whereas the downregulated genes were enriched in pathways related to infection, immune defense, and chemical signaling

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The reason why cells can generally sustain their NAD + levels and, therefore, their viability, is because they can salvage NAD + via multiple endogenous and exogenous precursors