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Griffith, O.W., Biologic and pharmacologic regulation of mammalian glutathione synthesis

Several studies specifically demonstrate Mgs protective effects against metals such as Cd, Cu, and Zn

Interestingly, the connection between FH and mTOR seems mutual: kidney-specific Tsc1 loss, which leads to constitutive mTOR activation, causes an mTOR-dependent downregulation of FH and the accumulation of fumarate, promoting renal epithelial transformation [85]

While the addition of merely 0.25 mM ATP to wild-type -syn monomers was adequate to begin the induction of fibril aggregation in a dose-dependent manner