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J Ethnopharmacol 200:147155 Yu Y, Matsuyama Y, Nakashima S, Yanase M, Kiuchi K, Ishiguro N (2004) Effects of MPSS and a potent iNOS inhibitor on traumatic spinal cord injury

Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC), a rate-limiting enzyme for glutathione synthesis, induced brain atrophy accompanied by neuronal loss and neuroinflammation

At minimum, their antioxidant properties complement melatonins actions in neutralizing the oxidative stress that accumulates with age and circadian misalignment ( To illustrate some of these findings, Table 2 provides a few examples of nutritional interventions studied for their effects on melatonin levels, sleep quality, and circadian-related outcomes in middle-aged or elderly populations: TABLE 2 Selected nutritional interventions as chronobiotics in aging

PLoS ONE 9 , e86300 (2014)