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third, disease severity is directly correlated with ADO levels, which are higher in patients with more severe prognoses

From a pathological evolution perspective, IVDD begins with the progressive destruction of the nucleus pulposus: the early stage is characterized by increased degradation of proteoglycans, leading to decreased water content in the NP and weakened biomechanical performance (reduced compressive load capacity), transferring more stress to the annulus fibrosus

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.Fang, E