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[62] GPCR-independent signaling by heterotrimeric G-proteins [edit] Although it is a relatively immature area of research, it appears that heterotrimeric G-proteins may also take part in non-GPCR signaling

GHK-Cu is a naturally occurring copper-binding tripeptide that penetrates the skin and signals fibroblasts to produce more collagen, elastin, and glycosaminoglycans