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This constant friction not only causes immediate pain but can also lead to chronic inflammation and infection if left untreated

Some may decide to settle after experiencing the locale, but most are likely to pass through and move on, either back from whence they came or on to another temporary haunt

In Fitzpatrick types IV to VI the main concern is post-inflammatory hyperpigmentation, so a clinic experienced with skin of color chooses the approach carefully, sometimes favoring gentler options

Mature RBCs, which lack nuclei and organelles, are particularly dependent on the pentose phosphate pathway because it is the only mechanism for them to generate NADPH