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the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics There's a study that people mention about D5 in a rat study showing tumors

Green tea composition, consumption, and polyphenol chemistry

Its sequence stability and robust purity profile allow researchers to obtain repeatable results in assays examining receptor-ligand interactions, peptide conformational dynamics, analytical quantification, and computational modeling