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(ii) myeloid cells: (a) the THP1 monocytic cell line, (b) the U937 and U1 (latently HIV1 infected) promonocytic cell lines, (c) primary human monocytederived macrophages (Shytaj et al , 2013), (d) human immortalized microglia (hglia) clone C20 (uninfected) and clone HC69 (latently infected with HIV1) (AlvarezCarbonell et al , 2017

ATM naturally exists as a resting inactive dimer which is auto-phosphorylated into an active monomeric form that interacts with the MRE11/RAD50/NBS1 (MRN) complex at the site of strand breaks, co-ordinating DNA repair 45,46