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If doses are missed, re-escalation may be necessary

Despite lower systemic absorption, it maintains local activity in the gut , offering significant benefits for: Ulcers and acid damage Leaky gut and intestinal inflammation NSAID-induced GI injury Key features: Shorter systemic half-life (~24 hours) Strong local effect on gastric mucosa Best used for digestive repair and mucosal protection Which Clears Faster

Additionally, pretibial myxedema occurs Due to dermal fibroblast stimulation that leads to GAGs deposition in the connective tissue