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Fortunatamente pi rara, e limitata esclusivamente a determinate categorie di pazienti a rischio, l'incidenza di disturbi neuro-psichici quali senso di agitazione ed alterazioni del comportamento

Compared to a diet rich in animal-based proteins and fats, a high-fiber diet particularly the Mediterranean diet, which enhances butyrate production and inhibits histone deacetylase (HDAC) activity through epigenetic mechanisms, thus preventing CRC cells proliferation

Maxillomandibular advancement surgery is part of Phase II surgery that may be considered if the patient does not respond (Qureshi, 2003)