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By heavily promoting GDNF expression, it reduces brain inflammation, clears out metabolic waste (like the amyloid plaques associated with aging), and revitalizes the dopamine system heavily taxed by modern life, stress, and previous stimulant use

Therefore, with a well selected population that would diminish the 95% confidence interval of relative risk of cardiovascular disease, we suggest that there might be an increased cardiovascular risk in the MTHFR TT mutants when folate status is low