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Upon ligand binding, TLRs recruit adaptor proteins primarily MyD88 or TRIF which activate downstream kinases including IRAKs and TRAF6, leading to the stimulation of transcription factors NF-B, AP-1, and IRF family members [33]

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Then, immediately 3 l of conditioned neurobasal medium (medium incubated with untreated neurons for the same number of days in vitro) was added to the grids