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Final diagnosis: These findings supported a diagnosis of tumefactive demyelinating lesion, with subsequent development of new characteristic demyelinating plaques further supporting a diagnosis of multiple sclerosis

The slightly greater HMOX1 induction by heme compared with heme-HPX is because the rate of heme diffusion into cells is significantly faster than the gradual, relatively slow and safe heme delivery via heme-HPX endocytosis (Smith and Morgan, 1981)